Fabrication and numerical optimization of microfluidic-based spiral micromixer

نوع مقاله : علمی-پژوهشی

نویسندگان

1 دانشکده مهندسی برق دانشگاه صنعتی سهند

2 عضو هیئت علمی دانشکده مهدسی برق، دانشگاه صنعتی سهند

چکیده

In this paper, recommended spiral passive micromixer was designed and simulated. spiral design has the potential to create and strengthen the centrifugal force and the secondary flow. A series of simulations were carried out to evaluate the effects of channel width, channel depth, the gap between loops, and flowrate on the micromixer performance. These features impact the contact area of the two fluids and ultimately lead to an increment in the quality of the mixture. In this study, for the flow rate of 25 μl/min and molecular diffusion coefficient of 1×10-10 m2/s, mixing efficiency of more than 90% is achieved after 30 (approximately one-third of the total channel length). Finally, the optimized design fabricated using proposed 3D printing method.

کلیدواژه‌ها

عنوان مقاله [English]

Fabrication and numerical optimization of microfluidic-based spiral micromixer

نویسندگان [English]

  • S. Pourhaji Agha Golestani 1
  • A. Pourmand 2
1 Faculty of Electrical Engineering, Sahand University of Technology, Sahand New Town, Tabriz, Iran.
2 Faculty of Electrical Engineering, Sahand University of Technology, Sahand New Town, Tabriz, Iran.| Institute for Polymer Materials, Sahand University of Technology, Sahand New Town, Tabriz, Iran.| Tissue Engineering and Stem Cells Research Center, Sahand University of Technology, Sahand New Town, Tabriz, Iran.
چکیده [English]

In this paper, recommended spiral passive micromixer was designed and simulated. spiral design has the potential to create and strengthen the centrifugal force and the secondary flow. A series of simulations were carried out to evaluate the effects of channel width, channel depth, the gap between loops, and flowrate on the micromixer performance. These features impact the contact area of the two fluids and ultimately lead to an increment in the quality of the mixture. In this study, for the flow rate of 25 μl/min and molecular diffusion coefficient of 1×10-10 m2/s, mixing efficiency of more than 90% is achieved after 30 (approximately one-third of the total channel length). Finally, the optimized design fabricated using proposed 3D printing method.

کلیدواژه‌ها [English]

  • Microfluidics
  • Micromixer
  • Drug Delivery System
  • Polymeric Micelles
  • Numerical Optimization

مراجع

[1]. Zargari, S., et al., A microfluidic chip for in vitro oocyte maturation. Sensor Letters, 2016. 14(4): p. 435-440.
[2]. Whitesides, G., The lab finally comes to the chip! Lab on a chip, 2014. 14(17): p. 3125-3126.
[3]. Manz, A., et al., Planar chips technology for miniaturization and integration of separation techniques into monitoring systems: capillary electrophoresis on a chip. Journal of Chromatography A, 1992. 593(1-2): p. 253-258.
[4]. Gubala, V., et al., Point of care diagnostics: status and future. Analytical chemistry, 2012. 84(2): p. 487-515.
[5] پورمند, همکاران, پیاده‌سازی و مشخصه‌یابی یک ریزشیر کواک با استفاده از مواد گرمانرم برای کاربردهای آزمایشگاه روی تراشه. مجله مهندسی برق دانشگاه تبریز, 2018, صفحه 1047-1058.
[6]. Cai, G., et al., A review on micromixers. Micromachines, 2017. 8(9): p. 274.
[7]. Beebe, D.J., G.A. Mensing, and G.M. Walker, Physics and applications of microfluidics in biology. Annual review of biomedical engineering, 2002. 4(1): p. 261-286.
[8]. Nguyen, N.-T. and Z. Wu, Micromixers—a review. Journal of micromechanics and microengineering, 2004. 15(2): p. R1.
[9]. Ward, K. and Z.H. Fan, Mixing in microfluidic devices and enhancement methods. Journal of Micromechanics and Microengineering, 2015. 25(9): p. 094001.
[10] طالب‌زاده,.همکاران, ارائه روشی نوین برای ساخت یک ریزمخلوط‌گر الکترواسمتیکی با الکترودهایی در دو سمت برای کاربردهای زیست-فناوری. مجله مهندسی برق دانشگاه تبریز, 2016. صفحه 255-265.
[11]. Ottino, J.M., The kinematics of mixing: stretching, chaos, and transport. Vol. 3. 1989: Cambridge university press.
[12]. Bayareh, M., M.N. Ashani, and A. Usefian, Active and passive micromixers: A comprehensive review. Chemical Engineering and Processing-Process Intensification, 2020. 147: p. 107771.
[13]. Gravesen, P., J. Branebjerg, and O.S. Jensen, Microfluidics-a review. Journal of micromechanics and microengineering, 1993. 3(4): p. 168.
[14]. Mehrdel, P., et al., Novel variable radius spiral–shaped micromixer: from numerical analysis to experimental validation. Micromachines, 2018. 9(11): p. 552.
[15]. Bahrami, D. and M. Bayareh, Experimental and numerical investigation of a novel spiral micromixer with sinusoidal channel walls. Chemical Engineering & Technology, 2022. 45(1): p. 100-109.
[16]. Raza, W. and K.-Y. Kim, Unbalanced split and recombine micromixer with three-dimensional steps. Industrial & Engineering Chemistry Research, 2019. 59(9): p. 3744-3756.
[17]. Tran-Minh, N., T. Dong, and F. Karlsen, An efficient passive planar micromixer with ellipse-like micropillars for continuous mixing of human blood. Computer methods and programs in biomedicine, 2014. 117(1): p. 20-29.
[18]. Wang, H., et al., Optimizing layout of obstacles for enhanced mixing in microchannels. Smart materials and structures, 2002. 11(5): p. 662.
[19]. Chen, X. and H. Lv, New insights into the micromixer with Cantor fractal obstacles through genetic algorithm. Scientific Reports, 2022. 12(1): p. 4162.
[20]. Vanka, S., et al. Novel low Reynolds number mixers for microfluidic applications. in Fluids Engineering Division Summer Meeting. 2003.
[21]. Raza, W., S. Hossain, and K.-Y. Kim, A review of passive micromixers with a comparative analysis. Micromachines, 2020. 11(5): p. 455.
[22]. Sudarsan, A.P. and V.M. Ugaz, Fluid mixing in planar spiral microchannels. Lab on a Chip, 2006. 6(1): p. 74-82.
[23]. Li, P., J. Cogswell, and M. Faghri, Design and test of a passive planar labyrinth micromixer for rapid fluid mixing. Sensors and Actuators B: Chemical, 2012. 174: p. 126-132.
[24]. Yang, J., et al., Design and fabrication of a three dimensional spiral micromixer. Chinese Journal of Chemistry, 2013. 31(2): p. 209-214.
[25]. Ghashghaie, F., et al., Preparation of Poly (dimethylsiloxane) Microparticles via a Co-flow Microfluidic Device and Investigation of Various Parameters Effect on Morphology. Journal of Applied Research of Chemical-Polymer Engineering, 2020. 4(3): p. 26-15.
[26]. Fox, R. and A. McDonald, Introduction to fluid mechanics, 1985. 1999, John Wiley, New York.
[27]. Chen, X. and L. Zhang, A review on micromixers actuated with magnetic nanomaterials. Microchimica Acta, 2017. 184: p. 3639-3649.
[28]. Hessel, V., H. Löwe, and F. Schönfeld, Micromixers—a review on passive and active mixing principles. Chemical engineering science, 2005. 60(8-9): p. 2479-2501.
[29]. Cosentino, A., et al., An efficient planar accordion-shaped micromixer: from biochemical mixing to biological application. Scientific reports, 2015. 5(1): p. 1-10.
[30]. Erickson, D. and D. Li, Influence of surface heterogeneity on electrokinetically driven microfluidic mixing. Langmuir, 2002. 18(5): p. 1883-1892.
[31]. Taheri, R.A. and V. Goodarzi, Numerical investigation of mixing improvement in a novel spiral microchannel with baffles. Engineering Analysis with Boundary Elements, 2022. 144: p. 518-529.
[32]. Vatankhah, P. and A. Shamloo, Parametric study on mixing process in an in-plane spiral micromixer utilizing chaotic advection. Analytica chimica acta, 2018. 1022: p. 96-105.

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