پیاده‌سازی و مشخصه‌یابی یک ریزشیر کواک با استفاده از مواد گرمانرم برای کاربردهای آزمایشگاه روی تراشه

نویسندگان

1 دانشکده مهندسی برق - دانشگاه صنعتی سهند - تبریز

2 مرکز تحقیقات ارتوپدی - دانشکده پزشکی - دانشگاه علوم پزشکی مشهد

چکیده

در سال‌های اخیر توجه روز افزونی به توسعه‌ی روش‌های جدیدی برای ساخت تراشه‌های ریزسیالاتی با استفاده از مواد جدیدی از خانواده‌ی گرمانرم‌ها، شده است. علت اصلی آن ویژگی‌های بسیار خوب مواد گرمانرم است که می‌تواند معایبی که ماده‌ی پلی دی متیل سیلوکسان (PDMS) دارد را برطرف کند. در این مقاله، یک روش ساخت بهینه‌شده، ارزان و سریعی را برای ساخت تراشه‌های ریزسیالاتی با استفاده از مواد گرمانرم گزارش شده است که برای ساخت آن از روش ریزماشین‌کاری لیزری و پیوند حرارتی استفاده می‌شود. از روش ریزماشین‌کاری لیزری برای حکاکی و بریدن صفحات آکریلیک و فیلم نازک پلی اورتانِ گرمانرم (TPU) استفاده شده است. پس از قراردادن لایه‌ها بر روی یکدیگر با استفاده از پیوند حرارتی لایه‌ها به یکدیگر پیوند یافته و در نهایت یک ریزشیر کواک برای کاربردهای ریزسیالاتی ساخته شده است. آزمایش‌های تکرارپذیری، قابلیت اطمینان و نشتی برای فشارهای مایع و کنترلی مختلف مورد مطالعه قرار گرفته‌اند که مشخص شد شیرهای ساخته‌شده توانایی مسدودکردن کانال را بدون هیچگونه نشتی، دارا می‌باشند. در نهایت، اثر تداخل عملکرد شیرهای یک کانال روی کانال مجاور نیز، به هدف توسعه‌ی کار برای کاربردهای آزمایشگاه روی تراشه مورد مطالعه قرار گرفته است.

کلیدواژه‌ها

عنوان مقاله [English]

Implementation and Characterization of a Quake Microvalve Using Thermoplastic Materials for Lab on a Chip Applications

نویسندگان [English]

  • A. Pourmand 1
  • S. A. Mousavi Shaegh 2
  • H. Badri 1
  • E. Najafi Aghdam 1
1 Electrical Engineering Department, Sahand University of Technology, Tabriz, Iran
2 Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده [English]

In recent years, there has been an increasing attention in developing inexpensive and easy microfluidic chips fabrication techniques using new materials from thermoplastic group. This is because of excellent properties of thermoplastics which can overcome the issues associated to poly(dimethylsiloxane). In the current investigation, an inexpensive, easy and rapid fabrication method was introduced and optimized to develop microfluidic chips using thermoplastic materials in which laser micromachining and thermal fusion bonding were used. Laser micromachining was used for cutting and engraving of poly(methyl methacrylate) sheets and thermoplastic polyurethane film. After alignment of layers, thermal fusion bonding was used to bond the layers and a Quack microvalve was successfully implemented for microfluidic applications. Repeatability, reliability and leakage free tests were done for various liquid and control pressures in which, results show that fabricated microvalve can block liquid channel without any leakage. Finally, interference effect of a channel’s valves on the neighboring channel was also studied to extend this work for lab on a chip design and applications.

کلیدواژه‌ها [English]

  • Microfluidics
  • quake microvalve
  • laser micromachining
  • thermoplastic materials
  • lab on a chip

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